Proteomics Scientist, Assay Research

At Seer, we are passionate about empowering our customers to expand scientific discoveries and achieve exceptional scientific outcomes. Our team is growing quickly as we develop innovative approaches to solve complex biological questions. And we believe the next frontier in biology is enabled through a clearer and more complete view of the proteome – something that Seer can uniquely deliver. As we build our team, we are looking for collaborative, driven, intellectually curious people who are committed to solving complex challenges. Our culture rewards accountability and cross functional teamwork, because we believe that this enables the kind of breakthrough thinking that will accelerate our mission. We are seeking a highly hands‑on Scientist to join our Assay Research team based in our Redwood City office. This role is ideal for a scientist who thrives at the bench and brings deep, practical expertise in immunoprecipitation (IP) workflows coupled to mass spectrometry (MS) . This role will contribute to new product concepts, development of novel ideas, investigation of diverse biological sample types, and optimization and operation of Seer’s core proteomics platform. The Scientist will have a proven track record in academia or the life sciences/pharmaceutical/biotechnology industry, with direct responsibility for designing, executing, and troubleshooting experiments . The successful candidate will have a strong background in proteomics with extensive experience preparing plasma or other biological samples for downstream MS analysis . Responsibilities Goals The Assay Research group designs, develops, and implements biochemical experiments, including automated workflows. Areas of specific responsibility include: Perform hands‑on experimental work at the bench , independently executing and optimizing proteomics assays with a strong focus on IP‑MS–based workflows. Design, execute, and troubleshoot immunoprecipitation experiments (e.g., antibody selection, bead chemistry, binding/wash/elution conditions) coupled to LC‑MS/MS analysis, including optimization of immunoprecipitation conditions for downstream bottom‑up mass spectrometry workflows . Prepare biological samples for mass spectrometry , including cell and tissue lysis, protein extraction, enrichment, cleanup, digestion, desalting, and quality control to ensure MS‑ready samples. Lead development of novel protein assay platforms, with specific emphasis on mass spectrometry–based protein detection and quantitative proteomics . Work with a wide range of biological samples (cells, tissues, FFPE, plasma/serum, or other complex matrices) and adapt various MS workflows accordingly. Conduct assay research, optimization, and protocol development; analyze and interpret experimental and MS data. Document experimental methods and results, including development of clear, transferable SOPs suitable for scale‑up and transfer to product development. Collaborate with automation engineers to translate manual IP‑MS and sample‑prep workflows onto automated liquid handling platforms. Partner with cross‑functional research teams to advance the product pipeline and maximize assay performance. Present data clearly in internal and external meetings; contribute to technical reports and publications as appropriate. Mentor junior scientists and research associates through hands‑on training in IP‑MS and MS sample preparation techniques. Background Qualifications The successful candidate will demonstrate scientific rigor, independence, and a strong experimental mindset. Key requirements include: Extensive hands‑on experience in immunoprecipitation coupled to mass spectrometry (IP‑MS) in an academic or industrial setting. Proven expertise in preparing samples for MS analysis , including protein extraction, enrichment, digestion, cleanup, and QC for LC‑MS/MS. Strong background in proteomics across a variety of biological sample types. Ability to design, execute, analyze, and i ... (truncated, view full listing at source)