Senior Scientist, Discovery Pharmacology

At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition as Science magazine’s No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK. For patients, for each other, and for the future of science, we’re in. Are you? About the Role: We’re seeking a highly motivated, organized, detail-oriented, collaborative, and passionate Senior Scientist to join our multidisciplinary team advancing therapeutics within the Immunology & Inflammation Therapeutic Area. In this role, you will lead the development, optimization, and validation of in vitro cell-based functional and translational assays; design, execute, and interpret microscopy-based experiments; and collaborate cross-functionally to support downstream analyses from in vivo studies. What You'll Do: Lead cell-based assay development, perform efficacy assessment across primary and follow-up compound screens, and support data-driven decisions for Insmed projects. Isolate and culture primary immune cells (neutrophils, hematopoietic stem/progenitor cells, mouse bone-marrow progenitors) and maintain common lines (e.g., PLB985, HL-60, THP-1, RAW264.7, Jurkat cells) and other relevant cell lines for in vitro/ex vivo assays. Plan and execute experiments using protein-based assays (e.g., Western blotting, ELISA, Luminex multiplex immunoassays). Perform immunofluorescence staining in cultured cells as well as immunohistochemistry on tissue sections. Conduct microscopy and analysis in partnership with computational scientists, help transition to a high-throughput, AI-driven workflow. Execute multicolor flow cytometry across immune and non-immune cell types, and perform high-purity FACS sorting of rare populations. Support downstream analyses from in vivo studies, including sample collection, processing, and ex vivo measurements. Maintain accurate, detailed, and timely electronic records of method development, experimental data, analyses, and summaries, and generate internal technical reports as needed. Perform data QC and statistical analyses to ensure accuracy, completeness, and validity, using Excel, XLfit, GraphPad Prism, and FlowJo. Conduct critical literature reviews to inform study design and program strategy. Ensure proper maintenance of laboratory equipment. Present scientific results at internal and external meetings as needed. Who You Are: PhD with 4+ years of experience in molecular and cellular biology, immunology, or a related field. Strong foundation and proven expertise in innate immunity, and in particular neutrophil biology, are required. Must have hands-on experience with cell culture and standard molecular biology assays, with deep knowledge of developing and optimizing in vitro assays to support target validation. Must have hands-on expertise in imaging techniques such as fluorescence microscopy, confocal microscopy, and high-content imaging systems. Strong hands-on experience with immunofluorescence staining and immunohistochemistry is required. Clear, effective communication (verbal and written) and strong problem-solving skills are required. A high degree of organization and time management skills, with meticulous attention to detail to ensure clarity, accuracy, and concision, are required. A strong sense of enthusiasm, autonomy, and self-motivation is required. Ability to work collaboratively and efficiently in a team environment is essential. Must successfully exhibit Insmed’s five (5) core corporate values: Passion, Accountability, Collaboration, Integrity and Respect. Nice to have (but not required): Experience workin ... (truncated, view full listing at source)