Research Associate, Single-Cell Genomics

Biohub is a 501(c)(3) biomedical research organization building the first large-scale scientific initiative combining frontier AI with frontier biology to solve disease. We build the technology to help scientists around the world use AI-powered biology to study how cells operate, organize, and work as part of systems to understand why disease happens and how to correct it. With our compute capacity, AI research and engineering, and state-of-the-art technology for measuring, imaging, and programming biology, we are enabling scientists worldwide to use AI-powered biology to advance our understanding of human health. The Team Our immune cell reprogramming team integrates foundational research on immunology and disease biology with AI-modeling to develop engineered cells that harness our own immune system to detect and treat early signs of age-related diseases, like cancer, Alzheimer’s, and Parkinson’s. These technologies will enable precise, context-dependent therapeutic responses only when and where it is needed. You can learn more about our work here . Our work brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine. Our Vision Pursue large scientific challenges that cannot be pursued in conventional environments Enable individual investigators to pursue their riskiest and most innovative ideas Facilitate research by scientists and clinicians at our home institutions and beyond We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease. The Opportunity Biohub is seeking a detail-oriented and collaborative Research Associate to support the development and operation of an Multiomics and Immune Profiling Lab (MIP Lab) situated inside Yale University (in the Biohub Yale Annex) . The MIP Lab will implement high-throughput multiomics and immune profiling including multimodal single cell profiling, as well as genetics and environment perturbation experiments with readouts from single-cell genomics and high-dimensional spatial profiling. This position is ideal for someone who is passionate about cutting-edge molecular technologies and thrives in a team-oriented, large-scale project environment. The mission of the Biohub—a collaborative effort between CZI, Yale, Columbia, and Rockefeller Universities—is to harness the human immune system for early disease detection and prevention. We are developing cutting-edge approaches to decode immune cell trafficking and sensing, engineer immune cells, and decipher the disease sensing code of immune cells throughout the body. The MIP Lab will implement and develop cutting-edge immune monitoring, profiling, and engineering technologies to support the mission of the Biohub and its Annex at Yale. The selected candidate will join a dynamic and exciting team and this position will allow the candidate to continue to build and expand their laboratory, scientific, and cross-disciplinary teamwork skills. What You'll Do Set up and maintain laboratory equipment and workflows for single-cell genomics and multiomics applications. Execute complex single-cell genomics experiments and coordinate sample processing with collaborating investigators and core facilities. Establish, troubleshoot, and optimize experimental pipelines and standard operating procedures for molecular and genomic technologies, including various types of omics library preparation. Perform quality control and preliminary computational analysis of genomic data to support experimental troubleshooting and workflow optimization. Maintain detailed documentation of protocols, experimental conditions, and results. Work closely with staff scientists, bioinformaticians, and other team members to support large-scale collaborative projects. Contribute to the training and mentoring of junior ... (truncated, view full listing at source)