Senior Research Associate, Cell & Molecular Biology

Company Summary: FL111 Inc., is a privately held, early-stage biotechnology company developing a groundbreaking small molecule technology platform. Our platform integrates experimental and computational approaches to unlock novel compounds to target high unmet-need diseases. FL111 is backed by Flagship Pioneering, bringing the vision and resources to guide FL111 from platform validation to real-world solutions that meaningfully improve patient care. Position Summary: FL111 is seeking a highly motivated Senior Research Associate with expertise in Cell and Molecular Biology to play a vital role in the company’s efforts to develop assays, screen compounds and integrate mechanism of action. This role requires a proactive, detail-oriented professional capable of working independently. Excellent written and verbal communication skills are essential. This is a unique opportunity to drive the growth of an early-stage biotechnology company in which you can contribute to the next frontier of small molecule medicines. Core Responsibilities: Mammalian cell culture of both cancer cell lines and primary cells, including generation of genetically modified cell lines Confident, competent and agile in establishing new, and running existing, cell-based and biochemical assays Self-starter who can work cross-functionally between in vitro Biology and in vivo pharmacology groups Analyze complex datasets, use appropriate statistics, provide meaningful interpretation Collaborate with team to develop experimental plans, document results in an ELN, and make presentations to report findings to team Qualifications and Skills: Bachelor’s degree in Cell and Molecular Biology or a related field (e.g. Pharmacology, Biochemistry, Biomedical Engineering), with at least 5 years experience or Master's degree with 3+ years of laboratory experience in the bio-pharmaceutical industry Experience with plate-based competition biochemical assays, Western analysis and immunofluorescence Experience with small molecule drug discovery, including compound management Hands-on experience with human/mouse cells (immortalized and primary) and using various delivery technologies (e.g. transfection, transduction, nucleofection, etc). Experience with ELN systems and data analysis workflows and database storage and retrieval Candidates of various experience levels will be considered. Position to be determined commensurate with experience. Additional Qualifications (preferred but not required): Experience with CRISPR-based gene manipulation: knockout, interference activation Experience with high content imaging, flow cytometry and quantitative PCR. Hands-on experience with human PBMCs About Flagship Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in generation of over 500 patents, initiation of over 50 clinical trials for novel therapeutic agents and an aggregate value of more than $90 billion. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com . Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual ori ... (truncated, view full listing at source)