Principal / Senior Principal, Security Architect
Lila SciencesSan Francisco, CA USAPosted 26 March 2026
Job Description
Your Impact at Lila
We’re looking for a Principal Security Architect to lead the security architecture for cloud applications operating at FedRAMP IL5 and IL6, while also shaping enterprise-wide security architecture and engineering.
This is a hands-on leadership role—your work will directly enable secure product delivery at speed. You’ll lead the design, implementation, and authorization of FedRAMP IL5/IL6 systems, then scale that success by building reusable security platforms, patterns, and practices across the organization.
What You'll Be Building
You will define and deliver secure cloud architectures that meet the highest federal standards while staying practical and engineer friendly. Your designs will become the foundation for multiple systems and scale across teams and environments.
FedRAMP IL5 / IL6 security architectures co-owned with Application Architects and applied across multiple systems
Deployable security designs grounded in NIST 800-53 Rev. 5, DoD Cloud SRG (IL5/IL6), and FedRAMP
Core security building blocks, including:
Identity, credential, and access management (ICAM)
Network segmentation, trust boundaries, and secure data flows
Encryption, key management, and secrets handling
Zero Trust architecture (NIST 800-207) implemented in production—not just documented
Reusable security platforms and patterns, including:
IAM and access control
Secrets management and key lifecycle
Logging, monitoring, and detection
Secure CI/CD and Infrastructure as Code
Enterprise reference architectures supporting both FedRAMP and non-FedRAMP systems
Compliance-aware designs that minimize authorization scope through control inheritance, reuse, and standardization
Automated compliance evidence pipelines that reduce manual effort and improve audit readiness
Security-by-design integrations embedded into product engineering and cloud infrastructure
Architectural support for resilience and response, including threat modeling, risk assessment, incident response, and forensic readiness
What Success Looks Like
Security controls are designed once and reused across applications and platforms
Compliance evidence is automated, repeatable, and scalable
Engineering teams adopt security patterns naturally, without friction
Security architecture accelerates delivery instead of slowing it down
This role is for someone who wants to build durable, reusable security architecture that scales beyond one system—and enables high-assurance cloud delivery at speed. This is not a policy-only or governance-only position.
What You’ll Need to Succeed
You bring deep, hands-on experience designing and delivering secure cloud systems in highly regulated environments. You’re comfortable translating complex requirements into scalable architecture and guiding teams through delivery.
8+ years in cybersecurity, security architecture, or security engineering
Proven, hands-on delivery of FedRAMP IL5 and/or IL6 systems, from design through authorization
Strong working knowledge of:
NIST 800-53 Rev. 5
DoD Cloud Computing SRG (IL5/IL6)
FedRAMP authorization and ATO processes
Cloud security architecture experience in AWS GovCloud
Experience securing cloud-native platforms, including:
Container orchestration (EKS, AKS, OpenShift)
CI/CD pipelines and Infrastructure as Code
Ability to explain control intent and risk tradeoffs, not just map requirements to controls
About Lila
Lila Sciences is the world’s first scientific superintelligence platform and autonomous lab for life, chemistry, and materials science. We are pioneering a new age of boundless discovery by building the capabilities to apply AI to every aspect of the scientific method. We are introducing scientific superintelligence to solve humankind's greatest challenges, enabling scientists to bring forth solutions in human health, climate, and sustainability at a pace and scale never experienced before. Learn more about this mission at
www.lila.ai
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