Senior Technical Program Manager - Preclinical, London

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery. Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture. The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you. About Iso Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases. We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI. Your impact As Isomorphic Labs accelerates its pipeline, we are approaching a critical inflection point: developing capabilities to deliver Iso’s ambition of multiple drug candidates per year. We are looking for a highly tactical and strategic Technical Program Manager to anchor this process. You will play a pivotal role in operationalising our path to the clinic, managing the complex sequencing of our first IND submissions. You will be the bridge between our scientific breakthroughs and regulatory reality, ensuring that our data management and documentation mature from research-grade to submission-ready standards. This is an opportunity for a "hands on" operator who can manage detailed logistics today, with the scope to grow as our development portfolio scales. What you will do Drive non-clinical IND needs : You will manage the timeline and sequencing of late-stage discovery including CMC, DMPK, pharmacology and tox reporting to enable successful submission, ensuring no critical path items are missed. You will partner closely with counterparts in our clinical team to ensure non-clinical and clinical aspects of the IND are integrated correctly. Program Management : Create and maintain rigorous project plans that monitor sequencing in a highly detailed way. You will track dependencies across multiple workstreams to ensure alignment with submission goals, including working with a network of external vendors and collaborators and managing large budgets. Data Management: Play a leading role in the transition of document and data management workflows from general cloud storage (e.g., Google Drive) to submission-ready systems. You will ensure our data integrity and documentation meet the regulatory standards required for development. Cross-Functional Coordination: Act as the operational hub for interdisciplinary teams, facilitating seamless communication between scientific teams, technical operations, and regulatory consultants to keep programs on track. Risk Mitigation: Proactively identify and document risks in the pre-clinical phase and devise ... (truncated, view full listing at source)