Manager, NGS Operations

POSITION SUMMARY: The Manager, NGS Operations oversees lab personnel and daily operations of sequencing instruments in support of research and development projects. The ideal candidate is both technically proficient and people-focused, able to balance hands-on problem solving with mentoring and developing a high-performing team. PRIMARY RESPONSIBILITIES: Manage daily scheduling and oversight of employees performing next generation sequencing (NGS) while fostering a collaborative, accountable, and growth-oriented team culture Manage Illumina sequencing workflows (NovaSeq X, Novaseq 6000, MiSeq i100, etc.) Monitor run level performance metrics (error rate, %Q30, cluster pass filter, % occupancy, etc) and troubleshoot instrument or library issues as needed Oversee PacBio Sequel and Revio operations, including instrument loading, run setup, and monitoring of key performance metrics (e.g., read length distribution, yield, accuracy/Q-scores), and troubleshoot instrument or library-related issues as needed Lead continuous improvement initiatives to optimize throughput, reduce turnaround times, and minimize errors, balancing speed with quality Serve as the primary point of contact for sequencing-related questions and workflow decisions, communicating clearly and proactively with stakeholders Maintain accurate records of lab work, ensure compliance with SOPs, and champion best practices in documentation and process adherence Collaborate closely with peer groups in Scientific Operations to align sample processing and sequencing workflows with project goals Provide hands-on support for troubleshooting and workflow optimization, while coaching team members to develop independence and confidence in their technical problem-solving Present team activity summaries, project updates, and performance metrics to management, highlighting successes, challenges, and opportunities for innovation Contribute to budget planning, capital equipment purchases, and vendor management for sequencing platforms and consumables, ensuring resources meet both current and future needs QUALIFICATIONS: BS/BA in a biological science or equivalent required; advanced degree preferred 5 years of related experience, 2+ years in a supervisory or leadership role KNOWLEDGE, SKILLS, AND ABILITIES: Hands-on experience with library preparation and next generation sequencing platforms, including Illumina (NovaSeq 6000, NovaSeq X, MiSeq i100) and PacBio (Sequel, Revio) Hands-on experience with nucleic acid techniques (isolation, purification, sonication, quantification, ampification, hybridization capture, etc.) Familiarity with laboratory automation a plus (Hamilton, Tecan, Biomek, Qiasymphony) Able to recognize lab issues and team concerns, communicate to management, and suggest improvements Knowledge of LIMS/database software Proficiency with Microsoft Office and Google Drive programs Excellent oral and written communication skills Ability to think creatively and analytically with strong troubleshooting and problem-solving skills Strong leadership and mentoring skills with a proven ability to motivate and develop technical staff Experience managing vendor contracts and evaluating technology platforms for lab implementation Ability to thrive in a fast-paced, evolving environment, and manage competing priorities efficiently Compensation Total Rewards This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations. This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including: Annual performance incentive bonus Long-term equity awards Comprehensive health benefits (medical, dental, vision) 401(k) with company match Generous paid time off and company holidays Additional wellness and work-life benefits Compensation Range $124,600 $ ... (truncated, view full listing at source)