Staff Scientist, Molecular and Cellular Biology (industry experience required)

Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date. We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team. We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment. For more information see: www.septerna.com . THE ROLE We are seeking an experienced Staff Scientist who will support Septerna’s small molecule drug discovery pipeline. They will design, execute, and analyze in vitro and ex vivo studies to assess pharmacology, mechanism of action, and efficacy of Septerna’s drug candidates. They will work both independently and collaboratively to develop and run assays, generate preclinical data, and contribute biological insights to advance programs toward the clinic. They may also engage in assay development and implementation of advanced in vitro/ex vivo modeling approaches to support Septerna’s translational efforts. The successful candidate will have the opportunity to demonstrate their scientific expertise and grow within our RD organization, contributing biological and physiological insights to projects as well as ideas for new therapeutic programs. The position is based in South San Francisco, CA. Title and compensation commensurate with experience. Key Responsibilities (include but are not limited to): Design and execute in vitro/ex vivo studies to evaluate therapeutic mechanisms of action in complex cell or ex-vivo models Generate, analyze, document, and interpret data to establish potency and efficacy relationships Help build and expand in vitro/ex vivo modeling capabilities Conduct literature reviews and interpret scientific publications to inform experimental design and troubleshooting Participate in project teams and present results at lab, team, and departmental meetings Author in vitro/ex vivo protocols, and study reports to support regulatory filings Follow all company policies and practices; maintain accurate and complete laboratory records and electronic notebooks Required Education, Skills Experience: PhD or MSc in Biology, Cell Biology, Molecular Biology, or a related field At least 5 years (or 9 years with MSc) hands-on experience in academia, biotechnology, or the pharmaceutical industry with tissue culture, including handling cell lines and primary c ... (truncated, view full listing at source)