Head of Clinical Sciences

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery. Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture. The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you. About Iso Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases. We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI. Your impact The experienced Head of Clinical Sciences will be the strategic architect of our clinical programs, leading studies from first in human (FIH) to proof-of-concept to registration. The role ensures clinical programs are aligned with corporate objectives, strategically designed, and deliver decision-ready data . Reporting to the Chief Medical Officer, this role will lead the protocol design and study delivery strategy. This role will work in close collaboration to establish, lead, and execute on the clinical development plan(s), and will have the opportunity to drive strategic decision-making to maximize the value of current and future clinical programs. Beyond the data, this role will champion a culture of scientific excellence, setting the bar for rigor and accountability as we scale our pipeline to reach patients faster. What you will do Lead the global clinical science strategy, endpoint selection, end-to-end protocol development, and associated amendment(s) across the full trial lifecycle, ensuring high level of quality and operational delivery. Spearhead the end-to-end clinical data review process, synthesizing complex data to deliver evidence-based strategic recommendations to executive leadership. Accountable for safety monitoring and risk management strategies, interpreting safety/efficacy data to guide critical decisions. Author and review key clinical and regulatory documents. Facilitate cross-functional collaboration to transition research stage assets to clinical development and integrate translational insights to influence broader program strategy. Represent the organization in health authority interactions and lead the scientific rationale for regulatory responses. Build and maintain strategic relationships with external partners (e.g., Key Opinion Leaders, Principal Investigators, and CROs) to validate program direction and support investor relations activities. Define and implement scalable clinical science best practices, SOPs, and governance frameworks to ensure speed, consistency, and inspection readiness. Defin ... (truncated, view full listing at source)