Sr. Director Evidence Generation

Mavericks Wanted When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical thoughtful use of AI to improve clarity, speed, and quality of work. What You’ll Do The Senior Director, Evidence Generation, Skeletal Dysplasia is a senior medical leadership role within Medical Affairs, responsible for developing and executing the integrated evidence generation strategy across BridgeBio’s skeletal dysplasia programs. Reporting to the CMAO, Skeletal and Endocrinology, this role will lead the design and implementation of real-world evidence (RWE), HEOR, Phase 4, registry, and investigator-sponsored research strategies to support clinical development, regulatory objectives, value demonstration, and lifecycle management. This leader will play a critical role in shaping the evidence strategy to support launch readiness and post-marketing commitments, while ensuring alignment across Clinical Development, Regulatory, Commercial, Market Access, and Field Medical. The role requires deep expertise in rare disease evidence generation, scientific rigor, and cross-functional leadership in a matrixed organization. Responsibilities Lead the development and execution of the integrated evidence generation strategy for skeletal dysplasia programs, aligned with overarching medical and asset strategy Design and oversee real-world evidence (RWE) initiatives, including registries, natural history studies, external data collaborations, and database analyses Partner with HEOR to generate data supporting value demonstration, payer engagement, and health technology assessment (HTA) requirements Lead Phase 4 planning and execution, including post-marketing commitments and lifecycle management studies Develop and manage investigator-initiated study (IIS) strategy and governance to address key scientific gaps Partner with Clinical Development to ensure evidence generation plans are integrated across development phases and support regulatory interactions Collaborate with Regulatory, Commercial, Market Access, and Patient Advocacy to ensure evidence plans address stakeholder needs Establish and maintain relationships with key opinion leaders (KOLs), academic investigators, and patient organizations within skeletal dysplasia and related specialties Represent BridgeBio at scientific congresses, advisory boards, and external forums Oversee evidence dissemination strategy in partnership with Scientific Communications, including publications and congress presentations Serve as medical reviewer and approver for relevant medical and cross-functional materials to ensure scientific accuracy and compliance Contribute to internal medical education and onboarding initiatives Where You’ll Work This role may be remote or hybrid/on-site in San Francisco. Who You Are MD, DO, PharmD, PhD, or equivalent advanced scientific or clinical degree 10+ years of experience in Medical Affairs, Clinical Development, HEOR, or Evidence Generation roles within the biopharmaceutical industry and/or academic medicine Demonstrated experience leading integrated evidence generation strategy in rare disease s ... (truncated, view full listing at source)