Director, Portfolio Strategy - Global Initiatives

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com . At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. Role Overview This is a high‑impact role at the intersection of science, strategy, and business, focused on shaping and advancing a differentiated BioMedicines RD portfolio from early discovery through clinical development and commercialization readiness. The role partners closely with senior BioMedicines and Flagship Pioneering leadership to define portfolio direction, build new RD programs, and drive high‑stakes investment and prioritization decisions. You will work hands‑on with scientific leaders, internal venture teams, and partnering colleagues to translate complex science into clear strategies, executable plans, and compelling executive narratives. Success in this role requires a roll‑up‑your‑sleeves mindset—owning analyses, building materials, structuring decisions, and moving work forward in a fast‑paced, ambiguity‑rich environment. What You’ll Do Shape portfolio strategy and investment decisions across the BioMedicines pipeline, from preclinical inception through development Build and advance new RD programs, defining development paths, milestones, resourcing plans, and decision points Develop integrated investment cases that synthesize scientific rationale, development feasibility, execution risk, and value creation Lead portfolio reviews, scenario planning, and trade‑off analyses (e.g., indication selection, timing, resourcing, probability‑adjusted value) Evaluate internal and external opportunities, including scientific, technical, strategic, and operational diligence of prospective assets Identify portfolio risks, gaps, and opportunities and recommend actions such as acceleration, de‑prioritization, partnering, or termination Translate complex scientific, clinical, and financial information into concise, executive‑level insights and decision materials Collaborate across RD, Clinical Development, Regulatory, CMC, Finance, Commercial, Partnering, and internal venture teams Work directly with senior scientific and executive leaders (e.g., CSOs, CMOs, CBOs) to create and execute new programs Support governance and decision‑making forums that enable speed, clarity, and accountability Contribute to special strategic initiatives with the Head of Global Initiatives and SVP, Global Initiatives Who You Are You are a scientifically trained strategist who thrives at the boundary of deep science and structured problem‑solving. You are comfortable operating with senior leaders and equally comfortable doing the work yourself—from framing questions to building analyses and influencing decisions. Qualifications PhD or MD in Life Sciences or a related field 5+ years of experience in management consulting (strategy and/or life sciences), biotech venture creation or investing, biopharma portfolio strategy, or related roles Strong understanding of biopharma RD, clinical development, and regulatory pathways Experience working across multiple programs and stages of drug development Demon ... (truncated, view full listing at source)