Scientist, Bioanalytical Assays

Company Summary: Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. Serif Biomedicines was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture. Position Summary: We are seeking a highly motivated and experienced Scientist with expertise in bioanalytical assays. This full-time bench scientist position requires expertise in bioanalytical platforms, LNPs, nucleic acid therapies, and biodistribution studies. This individual will have the opportunity to directly contribute to the bioanalytical assay development for platform and therapeutic areas, and work in a dynamic and fast-paced entrepreneurial environment as part of a highly collaborative team. Key Responsibilities: Design, develop, optimize, and execute bioanalytical assays to support nonclinical studies, including PK, PD, biomarker, and immunogenicity endpoints Execute ligand-binding assays and cell-based assays, ensuring robust assay performance, data quality, and compliance with applicable guidelines Design, optimize, and execute biodistribution studies (flow cytometry and histological techniques) for LNP/nucleic acid therapies Collaborate closely with CMC, molecular biology and cell biology teams to screen cargoes (immunogenicity assessment etc.) and ensure timely delivery of high-quality data and summarize results Establish and execute various cell-based assays to assess immunogenicity to nucleic acid cargoes and establish release criteria for preclinical payloads Design, establish and execute assays for assessing various in vivo immunogenicity predictors for LNP/nucleic acid therapies including but not limited to biomarkers, cytokines, complement activation and anti-drug antibodies (ADA) Execute test procedures such as sample extraction and measurement by flow cytometry, ELISA, MSD, Luminex, bDNA, ddPCR, RNAscope and perform data interpretation Analyze and summarize scientific data and maintain timely documentation and completion of electronic lab notebooks in compliance with industry guidelines Present at project team meetings and to relevant stakeholders Qualifications: Ph.D. in biochemistry, pharmaceutical sciences, cell biology or related field with 2 plus years of industry experience Proficiency in ddPCR, ligand binding assays and histological techniques Experience developing bioanalytical methods to measure drugs and biomarkers for LNP delivery of nucleic acid cargoes Strong communication, presentation and interpersonal skills Experience with non-viral delivery technologies and nucleic acid modalities is preferred Attention to detail, strategic thinking, problem solving, and decision-making skills We are an equal opportunity employer . All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification . If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, ... (truncated, view full listing at source)