Senior Microsoft Systems Engineer

Senior Microsoft Systems Engineer Who We Are: Xenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team. What We Do: We are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting, and continue to advance an early-stage pipeline of novel therapeutic candidates. In 2025, we initiated Phase 1 trials for XEN1701 (targeting Nav1.7) and XEN1120 (targeting Kv7). Nav1.7 and Kv7 are important pain targets, and data from these Phase 1 studies are expected in 2026 to support Phase 2 proof-of-concept studies in acute pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations. About the Role: We are seeking a Senior Microsoft Systems Engineer, to join our team. This role will serve as the Technical Lead for Generative AI, Collaboration Tools, and Workplace Systems. The Senior Microsoft Systems Engineer will serve as the platform owner for Microsoft 365 and Copilot AI. The successful candidate will also play a hands-on role with technical support escalations, requiring frequent interactions with vendor support and consultants on behalf of the team. Initial focus will be on Copilot governance, Microsoft 365 platform optimization, and secure collaboration capabilities, with Workplace Systems ownership expanding over time. During this period of rapid growth, this role may be assigned additional responsibilities (beyond Microsoft platforms and the core responsibilities described above). This position reports to the Senior Director, End User Solutions and will be based onsite in Needham, MA, USA. The level of the position will be commensurate with the candidate’s education and industry experience. RESPONSIBILITIES: - Serve as the technical system owner for the Microsoft 365 platform (including Copilot AI, Office Apps, Exchange, Teams, SharePoint, etc.). - Serve as the technical system owner for Workplace Systems (including Conference Room Audio-Visual Systems, Print Services, Visitor Registration, and Desk Reservation). - Serve as a domain administrator for Active Directory and Entra ID. Partner with the Infrastructure Team on managing users and devices in Entra ID, enterprise applications, and role-based access controls. - Continuously review the latest Copilot releases. Test and evaluate Frontier offerings to determine fit for use. Promote adoption of agentic featu ... (truncated, view full listing at source)