Senior Staff Product Engineer (Mechanical)

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Position Summary: This role is responsible for supporting product lifecycle activities, including new product introduction, product transfer, and ongoing manufacturing operations. This role ensures product quality, yield, and compliance through engineering evaluation, troubleshooting, and continuous improvement initiatives. Collaborates cross-functionally to drive process enhancements, cost optimization, and operational excellence, enabling smooth transition from design to production and sustaining high-performance standards throughout the product lifecycle. Position Responsibilities: Common Responsibilities: Support and drive product transfer into manufacturing. Perform data trending and analysis. Apply FMEA, DOE, and statistical analysis to optimize product quality and reduce costs. Drive process improvements, cost reduction, and product sustaining activities. Manage Engineering Change Request and Notifications (CRs and CNs), including updates to work instructions and test requirements. Support documentation: engineering drawings, BOMs, test reports, assembly procedures, and validation plans. Participate in continuous improvement initiatives and operational excellence programs. Frequent cross-functional collaboration and occasional travel to other sites. Provide guidance and mentorship to junior staff. Discipline-Specific Responsibilities: Mechanical Engineering Strategy & Architecture Set long-term technical roadmaps; guide platform interfaces (mechanical/thermal/fluidics/precision motion/structure/electro‑mechanical). Approve critical architecture decisions; define reliability targets. Standards & Governance Establish/own global design standards, verification/validation frameworks, and change control policies, drive compliance maturity. Sponsor cross-site technical councils and knowledge systems. Innovation & Technology Identify enabling technologies; lead feasibility and pilot integrations (e.g., advanced thermal management, precision mechanisms, smart fixtures, reliability engineering. Enterprise Impact Orchestrate multi-program cost/quality roadmaps; balance portfolio-level trade-offs. Advise executives; provide decision memos with quantified risk/benefit. Quality, Reliability & Data Define enterprise standards for data-driven decision-making. Sponsor predictive analytics and AI-driven insights for reliability and cost. Mentor leaders on statistical thinking and evidence-based governance. Consistently validates strategic decisions with robust data models. Sets cultural expectation: “No data, no decision.” Coaches’ directors and managers on interpreting analytics for portfolio decisions. Mentorship & Talent Coach staff/senior engineers; elevate technical career paths; define competency matrix and training. Listed responsibilities are an essential, but not exhaustive list, of the usual duties associated with the position. Changes to individual responsibilities may occur due to business needs. Position Requirements: Typically requires a minimum of 12 years of related experience with a Bachelor’s Degree; or 8 years and a Master’s Degree; or a PhD with 5 years’ experience; or equivalent experience. Deep expertise in thermodynamics, heat transfer, vibration, stress analysis and mechanical system behavior. Abl ... (truncated, view full listing at source)