Director of In Vivo Pharmacology

<div class="content-intro"><p style="line-height: 1.2;"><span style="font-family: arial, helvetica, sans-serif; font-size: 12pt;">Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three RD sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.</span></p> <p style="line-height: 1.2;"> </p> <p style="line-height: 1.2;"><span style="font-family: arial, helvetica, sans-serif; font-size: 12pt;">Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.</span></p> <p style="line-height: 1.2;"> </p></div><div class="col-xs-12 no-horiz-padding"><hr> <p><span style="font-size: 12pt; font-family: arial, helvetica, sans-serif;">Legend Biotech is seeking <strong>Director of In Vivo Pharmacology</strong> as part of the <strong>Research Early Development </strong>team based in <strong>Philadelphia, PA. </strong></span></p> <p><span style="font-size: 12pt; font-family: arial, helvetica, sans-serif;"><strong>Role Overview</strong></span></p> <p class="drawer-body-p"><span style="font-family: arial, helvetica, sans-serif; font-size: 12pt;">We are seeking an experienced and highly motivated Director of In Vivo Pharmacology to lead and expand our in vivo research capabilities in support of our cell and gene therapy pipeline. The successful candidate will be responsible for designing and overseeing preclinical pharmacology studies to evaluate the efficacy, safety, and mechanism of action of engineered cell or gene therapies in relevant in vivo models. This leadership role will be instrumental in guiding the transition of novel CAR-T candidates from discovery through IND-enabling studies and into early clinical development.</span></p> <p><span style="font-size: 12pt; font-family: arial, helvetica, sans-serif;"><strong>Key Responsibilities</strong> </span></p> <ul> <li style="font-family: arial, helvetica, sans-serif; font-size: 12pt;"><span style="font-family: arial, helvetica, sans-serif; font-size: 12pt;">Lead the strategic direction and execution of in vivo pharmacology studies supporting cell or gene therapy development programs.</span></li> <li style="font-family: arial, helvetica, sans-serif; font-size: 12pt;"><span style="font-family: arial, helvetica, sans-serif; font-size: 12pt;">Design, develop, and validate in vivo models (e.g., xenograft, syngeneic, orthotopic) to evaluate CAR-T efficacy, persistence, trafficking, and toxicity.</span></li> <li style="font-family: arial, helvetica, sans-serif; font-size: 12pt;"><span style="font-family: arial, helvetica, sans-serif; font-size: 12pt;">Oversee in vivo study execution in-house and at CROs, ensuring scientific rigor, quality, and compliance with regulatory standards.</span></li> <li style="font-family: arial, helvetica, sans-serif; font-size: 12pt;"><span style="font-family: arial, helvetica, sans-serif; font-size: 12pt;">Work cross-functionally with discovery, translational biology, immunology, and clinical teams to integrate pharmacodynamic, biomarker, and mechanism-of-action data.</span></li> <li style="font-family: arial, helvetica, sans-serif; font-size: 12pt;"><span style="font-family: arial, helvetica, sans-serif; font-size: 12pt;">Interpret and present data to internal stakeholders, executive leadership, and externa ... (truncated, view full listing at source)