Scientific Software Engineer (Full Stack)

(ID: 2025-0915) Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH). Benefits We Offer: 100% Medical, Dental Vision Coverage for Employees Paid Time Off and Paid Holidays 401K match up to 5% Educational Benefits for Career Growth Employee Referral Bonus Flexible Spending Accounts: Healthcare (FSA) Parking Reimbursement Account (PRK) Dependent Care Assistant Program (DCAP) Transportation Reimbursement Account (TRN) Overview Axle is seeking a Scientific Software Engineer that will develop the integration middleware and interactive interfaces for the SOM Center. This position involves building cloud-native applications that establish interoperability between cloud-based AI services, legacy laboratory systems, and real-time experimental state systems, delivering a unified data management interface for scientific discovery data. Responsibilities API Development: Design and implement high-concurrency asynchronous APIs (using GraphQL or gRPC) to stream data between cloud inference endpoints (e.g., Vertex AI) and centralized state stores. AI-Assisted Development: Actively utilize AI-assisted coding tools (e.g., GitHub Copilot) to accelerate feature implementation, unit testing, and debugging. User Portal Visualization: Develop the SOM User Portal using modern frameworks to render interactive visualizations. Implement WebGL-based components (e.g., Deck.gl, PixiJS) to render high-density parallel protocol topologies and multi-omics heatmaps without performance degradation. Agentic AI Integration: Implement the application logic to support Agent-based workflows, connecting user-facing chat interfaces with backend reasoning engines. Handle complex interaction patterns such as tool execution loops, multi-step reasoning chains, and streaming responses to the user. LIMS Integration Ontology Enforcement : Develop business logic to integrate modern microservices with Legacy Laboratory Information Management Systems (LIMS). Enforce Ontology Mapping at the user interface level to ensure all data entry adheres to the SOM controlled vocabulary. Real-Time State Store : Implement a high-frequency experimental state store using in-memory databases (e.g., Redis), utilizing WebSockets or Server-Sent Events (SSE) to power real-time dashboards that reflect experimental data states. Cloud-Native Patterns: Implement Cloud-Native design patterns to reliably consume outputs from asynchronous cloud operations and surface results to the user. Collaboration: Collaborate with AI researchers to create explainable interfaces for model predictions. Required Qualifications Bachelor’s or master’s degree in computer science or software engineering with experience in full-stack development for data-intensive applications. Proficiency in modern Python backend frameworks (FastAPI, Litestar) and strongly typed frontend ecosystems (React/Next.js with TypeScript). Experience with WebGL-based visualization libraries (e.g., Deck.gl, PixiJS, or Plotly) for rendering high-density biological datasets. AI Productivity: Demonstrated ability to leverage AI-driven coding assistants and LLMs to increase development velocity and code quality. Experience deploying and debugging applications in Containerized Cloud Environments (Cloud Run, ECS, or Kubernetes). Preferred Qualifications Familiarity with Agentic AI frameworks (e.g., LangChain, LangGraph, AutoGen) and implementing "Tool Use" patterns in applicati ... (truncated, view full listing at source)