Staff DevOps Engineer

Weave
San Francisco Bay Area, CA$200k – $250kPosted 27 February 2026

Job Description

<div class="content-intro"><h1><strong>Why Weave Exists</strong></h1> <p>At Weave, our mission is to evolve how therapeutic knowledge is captured, transformed, and communicated throughout drug development. We do this by equipping human experts with AI instruments to enable drugs to be brought to patients as rapidly, safely, and inexpensively as possible.</p> <p>The Weave Platform streamlines regulatory workflows from start to finish by intelligently, creatively, and effectively infusing every step with AI. Together with our customers, Weave is designing and building the AI workbench for the entire therapeutic lifecycle.</p></div><h1><strong>The Role Your Mission</strong></h1> <p>We’re looking for a <strong>Staff DevOps Engineer</strong> to own and evolve the infrastructure, reliability, and operational foundations of the Weave Platform. This role is critical to ensuring that our AI-driven systems are <strong>secure, performant, resilient, and compliant</strong> as we scale.</p> <p>Reporting closely to engineering leadership, you will be responsible for designing, operating, and continuously improving our cloud and on-premise environments. You will make high-leverage architectural decisions, establish best practices, and act as a force multiplier for the entire engineering team by enabling fast, safe, and reliable delivery of product features.</p> <p>You’ll be successful in this role if you can take ownership of ambiguous infrastructure problems, design pragmatic solutions, and operate them in production with a strong bias toward simplicity, observability, and resilience. We value stable, well-understood systems over unnecessary complexity, and we expect you to balance velocity with rigor especially in a regulated environment.</p> <h1><strong>What You'll Own</strong></h1> <ul> <li><strong>End-to-End Infrastructure Ownership:</strong> Design, operate, and evolve Weave’s cloud and on-premise environments (including potential AWS ownership), ensuring reliability, scalability, and maintainability across single-tenant and hybrid deployments.</li> <li><strong>Deployment, Performance Reliability:</strong> Build and maintain robust CI/CD pipelines; own deployment velocity, uptime, and system performance; implement strong observability (monitoring, logging, alerting); and lead incident response and root cause analysis.</li> <li><strong>Security, Networking Compliance:</strong> Architect and enforce infrastructure security best practices, including VPC/network design, IAM, and secure cloud-to-on-prem connectivity, while supporting compliance in a regulated environment.</li> <li><strong>Disaster Recovery Business Continuity:</strong> Design, test, and maintain backup and disaster recovery strategies to ensure rapid recovery and system resilience.</li> <li><strong>Operational Enablement Systems Management:</strong> Establish infrastructure standards, documentation, and automation that enable engineering velocity; oversee foundational IT and access management to ensure operational hygiene as the company scales.</li> </ul> <h1><strong>What You’ll Bring</strong></h1> <ul> <li>8+ years of experience in DevOps, Site Reliability Engineering, or Infrastructure Engineering roles.</li> <li>Experience operating production systems at an <strong>early-stage or growth-stage startup</strong>, with comfort owning broad surface area.</li> <li>Deep hands-on experience with <strong>cloud infrastructure (AWS preferred)</strong>, including networking, security, and cost management.</li> <li>Experience managing <strong>on-prem or hybrid environments</strong> in addition to cloud infrastructure.</li> <li>Strong understanding of Linux systems, networking fundamentals, and infrastructure automation (e.g., Terraform, CloudFormation, Ansible, or similar).</li> <li>Proven experience designing <strong>CI/CD pipelines</strong>, deployment strategies, and production observability.</li> <li>Pragmatic, analytical thinker who prioritizes reliability, simplicity, and opera ... (truncated, view full listing at source)
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