Postdoctoral Fellow, Mass Spectrometry

Biohub is a 501(c)(3) biomedical research organization building the first large-scale scientific initiative combining frontier AI with frontier biology to solve disease. We build the technology to help scientists around the world use AI-powered biology to study how cells operate, organize, and work as part of systems to understand why disease happens and how to correct it. With our compute capacity, AI research and engineering, and state-of-the-art technology for measuring, imaging, and programming biology, we are enabling scientists worldwide to use AI-powered biology to advance our understanding of human health. The Team Our decoding inflammation team builds tools to enable precise molecular-level measurements of inflammation within human tissues in real time, and develop proactive, early interventions that can be deployed when inflammation — which underlies the most significant causes of death worldwide — first flares in the body. You can learn more about our work here . Our team collaborates with three powerhouse universities - Northwestern University, the University of Chicago, and the University of Illinois Urbana-Champaign - to develop first-in-class technologies and make breakthroughs. Our Vision Pursue large scientific challenges that cannot be pursued in conventional environments Enable individual investigators to pursue their riskiest and most innovative ideas Facilitate research by scientists and clinicians at our home institutions and beyond We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease. The Opportunity Biohub in Chicago seeks outstanding early-career scientists and engineers to join its Mass Spectrometry Omics platform as a Postdoctoral Fellows in low-input and single-cell proteomics. This role offers a unique opportunity to work hands-on in a generously funded, highly collaborative environment at the intersection of technology development, biology, and disease-focused discovery. Postdoctoral Fellows will be embedded in interdisciplinary teams developing and applying next-generation proteomics workflows for ultra-low-input and single-cell measurements. A central focus of this role is understanding how cell-to-cell proteome heterogeneity shapes the behavior of immune-competent organoid systems. The successful candidate will leverage advanced proteomics to interrogate cellular diversity, immune–tissue interactions, and emergent phenotypes that are inaccessible with bulk approaches. This position provides strong mentorship alongside meaningful scientific independence within a team-science model that emphasizes collaboration across experimental, computational, and engineering domains. Projects align with the Biohub’s mission to uncover fundamental disease mechanisms and to develop transformative measurement technologies that accelerate biomedical research. Biohub Chicago is deeply committed to training scientists for impactful careers in academia, industry, and beyond. What You'll Do Design and execute low-input and single-cell proteomics experiments to investigate proteome heterogeneity in immune-competent organoid systems. Develop, optimize, and apply advanced mass spectrometry workflows for ultra-low-input samples, including method development, benchmarking, and quality control. Collaborate closely with interdisciplinary teams spanning tissue engineering, immunology, computation, and instrumentation to build and interrogate increasingly complex immune-organoid models. Analyze and interpret large-scale proteomics datasets using state-of-the-art computational pipelines, and communicate results clearly through figures, presentations, and internal discussions. Disseminate research outputs through high-impact publications, preprints, and open scientific resources, contributing to a culture of open and collaborative science. What You'll Bring Essential - PhD in proteo ... (truncated, view full listing at source)