Senior Research Associate, Protein Science

Company Description Flagship Labs 110 Inc. (FL110) is a privately held, early-stage technology company developing a fully integrated, end-to-end platform to enable next generation proteomics. Our platform integrates groundbreaking innovations in bioengineering, machine learning, and custom microelectronics to offer a level of precision and insight never before achieved. FL110 is backed by Flagship Pioneering, which brings the courage, long-term vision, and resources needed to realize unreasonable results. We are uniquely cross-functional and collaborative. Our teams thrive in unstructured and creative environments. Therefore, we seek individuals with an inclusive mindset and a diversity of thought. If this sounds like an environment you’d love to work in, even if you only have some of the experience listed below, please apply. About the Role We are seeking a highly motivated Senior Research Associate with experience in recombinant protein expression, purification, and characterization to support the development of FL110’s next-generation protein sequencing platforms and products. In this role, you will design, execute, and optimize protein production workflows from construct design through biochemical and biophysical characterization. You will work in a collaborative, interdisciplinary environment where teams rapidly interpret and respond to experimental results to guide platform development. The ideal candidate is an organized and creative experimentalist who enjoys troubleshooting challenging protein targets and contributing to new technologies. Basic Requirements BS or MS degree in Biochemistry, Molecular Biology, or a related field, with 4+ years of research experience in an academic or industry laboratory. Extensive hands-on experience in bacterial recombinant protein expression and purification, spanning the full workflow from DNA construct design and transformation through chromatographic purification using affinity, ion-exchange, and size-exclusion techniques. Proficiency with ÄKTA purification systems, including designing and executing protein purification methods. Familiarity with analytical techniques used to assess recombinant protein quality. Strong organizational skills and the ability to document experimental work in an ELN and maintain records in an electronic LIMS. Strong Candidates Will Have Ability to independently design, execute, troubleshoot, and interpret experiments related to protein expression, purification, and stability. Hands-on work with nanopore-forming proteins or related membrane protein systems. Familiarity with automation in a biochemistry setting. Experience developing functional assays to evaluate protein activity or performance. A track record of improving protein yield through construct and protocol optimization. Key Responsibilities Design, express, purify, and characterize soluble and membrane proteins. Develop and optimize expression and purification strategies for challenging protein targets. Design and evaluate new protein constructs and variants informed by experimental results. Characterize proteins using biochemical and biophysical methods to assess purity, stability, and function. Collaborate with experimental and computational teams to interpret results and guide future protein and nanopore designs. Document experimental workflows and contribute to shared lab knowledge and technical documentation. About Flagship Pioneering Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been rec ... (truncated, view full listing at source)