Zyphore - Associate Director/Principal Scientist, Pharmacology

About Raven: We are Raven, RA Capital’s healthcare incubator. From discovery to delivery, whether we incubate, accelerate or rejuvenate, Raven’s goal is to turn scientific breakthroughs into transformative therapies and get them quickly, safely and efficiently to the patients that need them most. Raven’s experienced scientists, operators, and healthcare innovators have deep sector expertise across therapeutics, diagnostics, devices and services. They have brought hundreds of therapeutics into development, managed hospital systems, optimized clinical trials and navigated payor and regulatory systems to deliver patient impact - and they are ready to work with you. About RA Capital: Founded in 2004, RA Capital Management is a multi-stage investment manager dedicated to evidence-based investing in public and private healthcare, life sciences, and planetary health companies. RA Capital creates and funds innovative companies, from private seed rounds to public follow-on financings, allowing management teams to drive value creation from inception through commercialization and beyond. RA Capital's knowledge engine is guided by our Tech Atlas internal research division, and Raven, RA Capital’s company building team, offers entrepreneurs and innovators a collaborative and comprehensive platform to explore the novel and the re-imagined. RA Capital has more than 150 employees and over $10 billion in assets under management. About Zyphore Zyphore is a cutting-edge biotechnology company focused on developing enzyme-based therapeutics to address diseases of metabolism and inflammation. By leveraging proprietary enzyme engineering, half-life extension (HLE), and immunogenicity shielding technologies, Zyphore aims to revolutionize enzyme-based therapeutics and provide best-in-class (BIC) therapies for patients. The Associate Director or Principal Scientist of Pharmacology will lead the pharmacology assay work for Zyphore’s Protein Engineering and Half-Life Extension strategies to enhance enzyme stability, activity, and immune shielding. This role will lead efforts in assay development, applying immunology, pharmacology, molecular biology, structural biology, and computational tools to select and characterize lead therapeutic molecules with enhanced function, stability, and developability, with a proven ability to lead cross-functional scientific teams. This researcher will also lead preclinical study design and manage external collaborations. You will drive scientific innovation while collaborating closely with colleagues in discovery biology, protein sciences, and translational science. This is a high-impact, hands-on leadership role ideal for an immunologist or pharmacologist with extensive immunogenicity experience passionate about creating biologics that make a difference for patients. Key Responsibilities ● Design and develop immunogenicity, pharmacokinetics, toxicokinetic and pharmacodynamics assays. ● Design preclinical studies and relevant assays. ● Manage external partnerships with preclinical study CROs, consultants, or academic labs as needed. ● Support plate-based enzymatic kinetics, activity, and protein stability assays. ● Support molecular cloning and construct variant libraries. ● Collaborate cross-functionally to align assay development with protein design, bioconjugation, bioanalytics, and downstream translational goals. ● Maintain detailed electronic lab notebooks and communicate findings effectively to the scientific team. ● Collaborate with cross-functional team members and external partners to drive programs aligned with strategic goals. ● Contribute to intellectual property strategy and write technical sections for patents and regulatory documents. ● Mentor junior scientists and help build a culture of scientific excellence and collaboration. Qualifications ● PhD in Immunology, Pharmacology, or related field. ● 8+ years of postdoctoral and industry experience in immunology, pharmacology, or biologics drug develop ... (truncated, view full listing at source)