Senior Scientist

At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition as Science magazine’s No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK. For patients, for each other, and for the future of science, we’re in. Are you? About the Role: Insmed is seeking a highly experienced and creative biologist, virologist, or bioengineer to lead discovery and engineering initiatives aimed at developing next-generation gene therapies for rare diseases. The successful candidate will work within a cross-disciplinary team of experimental and computational scientists, performing wet-lab research to advance program objectives. This role is available at the Senior Scientist level. What You'll Do: Lead biological engineering projects focused on development of next-generation viral vectors Independently design, optimize, and execute high-throughput molecular and cellular screening systems to identify and characterize novel viral capsids. Support viral vector projects, including transfection, transduction, viral titering, and sequencing-based characterization of viral genomes. Implement advanced molecular biology methods to design and build high diversity viral vector libraries Design, optimize, and execute molecular biology workflows, including DNA/RNA extraction, cloning and PCR/qPCR/ddPCR Prepare Next-Generation Sequencing (NGS) libraries (Illumina, Nanopore, PacBio) and perform quality measurements (qubit, tape station). Perform cell culture with mammalian cell lines and primary cells Design, conduct, and support in vivo studies Document protocols, write reports, and present findings to cross-disciplinary teams Contribute to laboratory operations, including training of junior staff and maintenance of high-quality research standards. Who You Are: PhD in cell biology, virology, immunology, molecular biology, bioengineering, or related field with 4+ years of relevant industry or relevant Post Doc experience or MS with 8+ years of relevant hands-on experience. Direct report or small team management experience strongly preferred. Proven track record in method development, including experimental design, optimization, execution, and evaluation. Experience with viruses or viral vectors including AAV. Experience with viral transfection, transduction, ultracentrifugation purification (CsCl, iodixanol), genome titer (by qPCR, ddPCR, RT-qPCR, RT-ddPCR) and characterization. Experience with viral vector engineering (large library preparation and screening). Experience working with mammalian cell lines and primary cells. Hands-on in vivo model or study management experience. Experience with cell-based functional assays including but not limited to ELISpot, ICS, flow cytometry, antibody-neutralization assays, and potency assays. Strong written and oral communication skills. Applicants should be detail-oriented, highly organized, and able to multi-task with multiple projects. Strong analytical and problem-solving skills a must. Nice to have (but not required): Background in advanced molecular biology methods including cloning and recombinant DNA technologies (DNA/RNA extraction, primer/probe design, PCR/qPCR/ddPCR, Gibson Assembly, Golden Gate etc.) Proficiency in NGS technologies (Illumina, Nanopore, PacBio), library preparation, and quality assessment (qubit, tape station). Experience with protein characterization methods, including but not limited to ELISA, SDS-PAGE, western blot, TFF, and affinity chromatography. Where You’ll Work This role is based out of our New Hampshire office and requires full-time, in-pers ... (truncated, view full listing at source)