Head of Translation

Company info NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Description NewLimit is recruiting a Head of Translation to lead our therapeutic programs from discovery to the clinic. Our active programs are focused on restoring youthful hepatic metabolism, vascular endothelial integrity, and T cell immunity in aged and diseased patients. In this role, you will lead the validation and preclinical development of reprogramming medicines through regulatory filing to early clinical development. You will serve as the company’s senior preclinical development scientist and as a member of our executive team. As part of your role, you will: Lead preclinical development and preparing regulatory filings (IND, CTNs, and others) for reprogramming medicines. You will be the primary owner of progress for our therapeutic assets. Manage all Therapeutic Area teams and coordinate with others to establish preclinical models, validate payloads, and complete development candidate selections. Solve the logistical bottlenecks that block progress of our therapies. This may involve coordinating CMC timelines, planning study schedules, or sourcing precious preclinical samples. You will get your hands dirty. Serve as a member of NewLimit’s Executive Team and contribute to budgeting, goal setting, and technical review decisions. Recruit, manage, and mentor scientists and therapeutic developers throughout the company. Requirements Ph.D. in molecular biology, developmental biology, chemistry or a related discipline or M.D./Pharm.D. and relevant clinical training or ≥5 years of equivalent industry experience Experience leading therapeutic programs through the investigational new drug application process History of technical contributions to therapeutic programs as a biologist, chemist, or computational scientist Experience managing substantial budgets and making go/no-go decisions Nice to have Experience contributing to a 0 → 1 medicine that was first-in-class for a new target category or modality Experience contributing to nucleic acid medicines (mRNA, RNAi, ASO) History of contributions in one of our current therapeutic areas (hepatic metabolism, vascular biology, immunology) Experience leading program teams across multiple therapeutic areas Experience with regulatory filings across multiple geographies (US, AUS/NZ, EU, MENA) Benefits Health, dental, and vision insurance 401(k) with company match Industry-leading paid time off (PTO) -- 20 days/year for all employees + holidays Paid parental leave Meals and snacks on-site Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Learn more at: https://www.newlimit.com/careers