Associate Director/Director, Translational Biology

Mavericks Wanted When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical thoughtful use of AI to improve clarity, speed, and quality of work. What You'll Do The Associate Director of Biomarker Science will be leading assay development, validation, and translational biomarker strategies across BridgeBio affiliate programs. This role requires a hands-on scientific leader who can design and validate assays, integrate biomarkers into clinical development, manage vendor partnerships, and communicate results to internal and external stakeholders. The successful candidate will operate at the intersection of discovery, preclinical development and clinical operations- providing scientific leadership and operational rigor to accelerate program decision-making. This position includes supervisory responsibilities: you will both lead scientific work and manage a team of scientists and technical staff, providing coaching, career development, resource planning and performance management. Responsibilities Discovery Biology Strategy Define the biology strategy to support target validation, mechanism-of-action studies, and medicinal chemistry optimization Design and execute in vitro and in vivo experiments that demonstrate target engagement, functional pharmacology and disease-relevant biology to inform med chem SAR and lead optimization Coordinate with medicinal chemistry, structural biology and pharmacology teams to prioritize compounds, define target product profiles, and support lead selection Translate discovery findings into criteria and experimental plans that feed into IND-enabling studies and inform go/no-go decision points Assay Development and Validation: Lead design, development and validation of biomarker and pharmacodynamic assays (cell-based, biochemical, ELISA/multiplex immunoassays, Western blotting, biophysical protein characterization, etc.) to support translational and clinical programs Set assay performance criteria and qualification/validation plans; author SOPs and validation reports; implement QA/QC practices to ensure reproducible assay performance Clinical Trial Support: Translate preclinical biomarker findings into clinical biomarker strategies and practical assay deployment plans Collaborate with clinical operations, sample management and biostatistics to design sample collection, processing, storage and chain-of-custody procedures Oversee incorporation of biomarker testing into Phase 1–3 protocols, including sample handling, endpoint definitions and analysis plans Vendor Management: Identify, qualify and manage relationships with external vendors, CROs and CLIA laboratories for assay development, transfer and routine execution Lead vendor qualification, technology transfer, assay bridging and vendor audits to ensure regulatory readiness and data quality Regulatory Compliance and Filings: Ensure biomarker assays and data collection comply with applicable regulatory standards (GCP/GLP where applicable) Contribute clinical assay sections and assay validation summaries for regulatory submissions (INDs, briefing packages, NDAs) ... (truncated, view full listing at source)