Senior Scientist

At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition as Science magazine’s No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK. For patients, for each other, and for the future of science, we’re in. Are you? About the Role: We’re looking for a Senior Scientist on the protein engineering team to help us expand what’s possible for patients with serious diseases. Reporting to the Senior Director, Research, you’ll work within a multidisciplinary team of scientists focused on the design, engineering, and preclinical characterization of ground-breaking biotherapeutics. Specifically, you will help lead engineering and optimization campaigns for a diverse array of biomolecular scaffolds including binding and targeting moieties, signaling molecules, enzymes, and biological drug delivery platforms. What You'll Do: In this role, you’ll have the opportunity to drive biomolecular engineering efforts within Insmed research projects, including strategy and methods development. You’ll also: Construct recombinant systems encoding protein variants and combinatorial protein libraries Conceptualize, construct, qualify, and implement high throughput screening platforms to enable candidate selection from large panels and/or combinatorial libraries of engineered protein variants Conduct precision protein engineering to achieve specified design objectives, working both independently and in collaboration with computational biologists Devise, optimize, and employ tailored protein expression and purification strategies for drug discovery programs Develop, qualify, and deploy quantitative functional assays to characterize protein performance in vitro Assess therapeutic candidate performance using in vivo models Contribute to collaborative prioritization and decision making on prospective discovery and development programs Maintain accurate, detailed, and timely records of methods development, experimental data, and data analysis Participate in cross-disciplinary mentoring and training within the RDL NH team Present scientific results to the RDL NH team, Insmed research department, and external scientific community as needed, and assist with coordination and day-to-day management of RDL NH site operations Who You Are: You have a PhD along with 5+ years of experience or MS degree along with 9+ years of experience in biochemistry, molecular biology, bioengineering or related field. You are or you also have: Deep technical understanding of, and hands-on experience with, molecular biology, recombinant DNA technology, protein mutagenesis, and protein biochemistry Expertise with recombinant protein expression and purification Expertise with routine protein characterization methods including but not limited to spectroscopy, SDS-PAGE, western blot, ELISA Experience with protein-protein binding analysis a must Proven track record in experimental methods development, including experimental design, execution, and evaluation Nice to have (but not required): Experience with enzyme analysis a plus Experience in high throughput functional screen development for protein libraries strongly preferred Experience with lab automation strongly preferred Experience with next-generation sequencing strongly preferred. Where You’ll Work This role is based out of our New Hampshire Research Development Lab and requires full-time, in-person presence to support hands-on collaboration, access specialized equipment, and/or operational needs. Travel Requirements Minimal travel expected Pay Range: $127,000.00-165,500.00 Annual Lif ... (truncated, view full listing at source)